Motif ID: RXR{A,B,G}.p2

Z-value: 1.902


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma



Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_44429748 5.230 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr14_-_103058568 2.356 CKB
creatine kinase, brain
chr12_+_50686990 2.159 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr8_-_71146103 1.771 NM_024504
PRDM14
PR domain containing 14
chr15_-_53822468 1.726 NM_173814
PRTG
protogenin
chr5_-_131591380 1.695 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr5_-_172688024 1.687 STC2
stanniocalcin 2
chr4_+_134292630 1.682 PCDH10
protocadherin 10
chr11_-_75595098 1.666 NM_004626
WNT11
wingless-type MMTV integration site family, member 11
chr8_-_71146022 1.653 PRDM14
PR domain containing 14
chr17_+_7125702 1.631 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr3_-_124650081 1.535 NM_183357
ADCY5
adenylate cyclase 5
chr22_+_18081968 1.421 NM_002688
SEPT5
septin 5
chr5_-_172687798 1.379 STC2
stanniocalcin 2
chr3_+_49566901 1.328 NM_003458
BSN
bassoon (presynaptic cytomatrix protein)
chr20_-_61933012 1.264 ZBTB46
zinc finger and BTB domain containing 46
chr22_+_48966394 1.253 TRABD
TraB domain containing
chr12_-_50502474 1.244 NM_001013690
FIGNL2
fidgetin-like 2
chr4_+_134293171 1.230 PCDH10
protocadherin 10
chr17_-_33178987 1.168 HNF1B
HNF1 homeobox B
chr22_+_48966480 1.168 NM_025204
TRABD
TraB domain containing
chr22_-_45037882 1.149 NM_006071
PKDREJ
polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
chr17_+_70431964 1.143 NM_178160
OTOP2
otopetrin 2
chr14_+_100270222 1.133 DLK1
delta-like 1 homolog (Drosophila)
chr22_+_18085990 1.108 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr17_-_6887965 1.097 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr22_+_18085891 1.089 SEPT5
septin 5
chr17_-_33179118 1.079 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr17_+_71097147 1.078 MYO15B
myosin XVB pseudogene
chr11_-_76059435 1.074 NM_001128922
LRRC32
leucine rich repeat containing 32
chr1_+_14797764 1.059 NM_015209
NM_201628
KAZN

kazrin, periplakin interacting protein

chr5_-_59225377 1.029 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_+_92946348 1.021 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr11_+_43920385 0.996 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr11_+_113436438 0.987 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr1_-_99242765 0.987 NM_001010861
NM_001037317
LPPR5

lipid phosphate phosphatase-related protein type 5

chr15_+_39008822 0.987 NM_019074
DLL4
delta-like 4 (Drosophila)
chr11_+_14621972 0.987 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr11_-_86343859 0.970 NM_012193
FZD4
frizzled homolog 4 (Drosophila)
chr19_+_447453 0.957 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr17_-_74433048 0.936 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr11_-_63440891 0.933 NM_173587
RCOR2
REST corepressor 2
chrX_+_69591639 0.922 NM_001166278
DLG3
discs, large homolog 3 (Drosophila)
chr7_-_124192265 0.905 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr5_-_114543632 0.904 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr6_+_137285071 0.903 NM_001008783
SLC35D3
solute carrier family 35, member D3
chr17_-_74432671 0.895 TIMP2
TIMP metallopeptidase inhibitor 2
chr12_+_79634820 0.894 NM_005593
MYF5
myogenic factor 5
chr3_+_129690735 0.886


chr11_-_69228286 0.849 NM_005117
FGF19
fibroblast growth factor 19
chr22_+_28446288 0.841 NM_182527
CABP7
calcium binding protein 7
chr8_-_57521702 0.837 NM_001135690
PENK
proenkephalin
chr4_-_2336328 0.829 NM_001172659
NM_001172660
ZFYVE28

zinc finger, FYVE domain containing 28

chr14_+_68796621 0.823 GALNTL1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
chr19_-_43412170 0.821 DPF1
D4, zinc and double PHD fingers family 1
chr18_+_2896956 0.816 EMILIN2
elastin microfibril interfacer 2
chr2_-_192767494 0.802 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr10_+_94439658 0.801 NM_002729
HHEX
hematopoietically expressed homeobox
chr15_-_50869379 0.798 NM_004498
ONECUT1
one cut homeobox 1
chr3_+_161426322 0.796 LOC401097
hypothetical protein LOC401097
chr15_-_38362078 0.785 NM_001190479
LOC100131244
hypothetical protein LOC100131244
chr8_-_26427304 0.782 NM_007257
PNMA2
paraneoplastic antigen MA2
chr17_+_78630793 0.782 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr14_+_60045621 0.768 NM_007374
SIX6
SIX homeobox 6
chr3_+_161425946 0.761 NM_001168214
LOC401097
hypothetical protein LOC401097
chr19_+_18584666 0.760 NM_012109
TMEM59L
transmembrane protein 59-like
chr3_-_127558747 0.753 NM_014079
KLF15
Kruppel-like factor 15
chr8_-_93184629 0.753 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr19_-_772913 0.752 NM_024888
LPPR3
lipid phosphate phosphatase-related protein type 3
chr19_-_18198234 0.751 NM_001098818
PDE4C
phosphodiesterase 4C, cAMP-specific
chr19_-_43412152 0.743 NM_001135156
DPF1
D4, zinc and double PHD fingers family 1
chr22_-_17892001 0.737 CLDN5
claudin 5
chr17_-_37828643 0.729 NM_012232
PTRF
polymerase I and transcript release factor
chr19_-_772966 0.722 LPPR3
lipid phosphate phosphatase-related protein type 3
chr10_-_80875097 0.717 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr13_+_48692472 0.717 NM_001507
MLNR
motilin receptor
chr22_-_17891777 0.712 CLDN5
claudin 5
chr3_+_131175803 0.706 NM_007117
TRH
thyrotropin-releasing hormone
chr11_-_86343737 0.706 FZD4
frizzled homolog 4 (Drosophila)
chr10_-_73518269 0.705 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr2_+_176724358 0.701 NM_014621
HOXD4
homeobox D4
chr17_+_7495436 0.698 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr7_-_120285245 0.691 TSPAN12
tetraspanin 12
chr14_-_37795001 0.691 CLEC14A
C-type lectin domain family 14, member A
chr1_-_47468029 0.686 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr17_-_74432800 0.685 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_57661373 0.684 DAB1
disabled homolog 1 (Drosophila)
chr11_-_30564338 0.671 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr19_+_18543613 0.670 NM_001033930
NM_003333
UBA52

ubiquitin A-52 residue ribosomal protein fusion product 1

chr3_-_38666122 0.667 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr2_+_241586927 0.665 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr10_-_73518284 0.660 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chrX_+_101267315 0.652 NM_080390
TCEAL2
transcription elongation factor A (SII)-like 2
chr14_+_76298693 0.650 VASH1
vasohibin 1
chr16_+_66129481 0.650 FAM65A
family with sequence similarity 65, member A
chr17_-_42411587 0.644 NM_203400
RPRML
reprimo-like
chr6_-_85529031 0.643 TBX18
T-box 18
chr11_-_9069668 0.640 NM_001170690
NM_020974
SCUBE2

signal peptide, CUB domain, EGF-like 2

chr17_-_7106497 0.639 CLDN7
claudin 7
chr2_-_192767844 0.636 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr1_-_1840564 0.628 NM_178545
TMEM52
transmembrane protein 52
chr4_-_154929657 0.627 NM_003013
SFRP2
secreted frizzled-related protein 2
chr16_+_162845 0.627 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr20_-_54013418 0.625 NM_080617
CBLN4
cerebellin 4 precursor
chr17_+_7151653 0.619 EIF5A
eukaryotic translation initiation factor 5A
chr7_-_107430566 0.617 NM_002291
LAMB1
laminin, beta 1
chr19_+_54314292 0.614 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr6_-_2916280 0.612 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr20_+_48032918 0.608 NM_005985
SNAI1
snail homolog 1 (Drosophila)
chr14_+_28306633 0.608 FOXG1
forkhead box G1
chrX_+_136476353 0.605 ZIC3
Zic family member 3 (odd-paired homolog, Drosophila)
chr7_-_150283794 0.604 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr12_+_50104859 0.604 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr17_-_76985538 0.603


chr12_+_52105131 0.603 AMHR2
anti-Mullerian hormone receptor, type II
chr14_-_60260211 0.599 NM_017420
SIX4
SIX homeobox 4
chr17_-_7106987 0.598 NM_001185023
NM_001307
CLDN7

claudin 7

chr2_-_228754585 0.598 NM_001142644
NM_030623
SPHKAP

SPHK1 interactor, AKAP domain containing

chr20_+_20296744 0.597 NM_002196
INSM1
insulinoma-associated 1
chrX_-_138114100 0.595 FGF13
fibroblast growth factor 13
chr7_-_126679540 0.594 NM_001127323
GRM8
glutamate receptor, metabotropic 8
chr1_+_27192719 0.593 NM_001013642
TRNP1
TMF1-regulated nuclear protein 1
chr19_+_14982538 0.591 NM_173482
CCDC105
coiled-coil domain containing 105
chr1_-_26245031 0.588 NM_001004434
NM_032513
SLC30A2

solute carrier family 30 (zinc transporter), member 2

chr11_+_817584 0.587 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr3_-_46710137 0.578 NM_001190707
NM_147129
ALS2CL

ALS2 C-terminal like

chr3_-_51968995 0.578 PCBP4
poly(rC) binding protein 4
chr7_+_78920846 0.577 LOC100505881
hypothetical LOC100505881
chrX_-_44945025 0.577 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr8_+_26427378 0.574 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr7_+_94374862 0.574 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr7_-_150306169 0.569 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr19_-_15421761 0.568 NM_021241
WIZ
widely interspaced zinc finger motifs
chr10_-_17536181 0.568 NM_001004470
ST8SIA6
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr2_-_27457088 0.564 NM_144631
ZNF513
zinc finger protein 513
chr10_-_134605978 0.558 NM_173572
C10orf93
chromosome 10 open reading frame 93
chr14_+_100263028 0.552 DLK1
delta-like 1 homolog (Drosophila)
chr22_+_43451351 0.550 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr1_-_86394695 0.548 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr17_+_26742767 0.546 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr5_-_92942680 0.546 FLJ42709
hypothetical LOC441094
chr20_+_3000265 0.545 NM_000915
OXT
oxytocin, prepropeptide
chr7_-_27191287 0.544 NM_005523
HOXA11
homeobox A11
chr6_+_21774624 0.542 FLJ22536
hypothetical locus LOC401237
chrX_-_30237403 0.540 NM_000475
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr5_+_149526533 0.540 NM_001804
CDX1
caudal type homeobox 1
chr17_+_63609317 0.539 LOC100499466
hypothetical LOC100499466
chr14_-_76807302 0.538 NM_021257
NGB
neuroglobin
chr17_+_56831951 0.536 NM_005994
TBX2
T-box 2
chr4_-_86106567 0.531 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr19_+_44697592 0.531 NM_182704
SELV
selenoprotein V
chr9_-_70818829 0.531 NM_002732
PRKACG
protein kinase, cAMP-dependent, catalytic, gamma
chr1_+_12149662 0.529 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr14_-_103058865 0.529 NM_001823
CKB
creatine kinase, brain
chrX_+_38305634 0.525 NM_004615
TSPAN7
tetraspanin 7
chr12_+_50587468 0.523 NM_000020
ACVRL1
activin A receptor type II-like 1
chr19_-_7244876 0.521 NM_000208
NM_001079817
INSR

insulin receptor

chr20_+_57612996 0.521 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr19_-_56260135 0.520 NM_015596
KLK13
kallikrein-related peptidase 13
chr20_+_44091219 0.518 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr4_+_2031036 0.518 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr7_-_78920806 0.516 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr19_-_18867868 0.515 NM_021267
NM_198207
NM_001492
LASS1

GDF1
LAG1 homolog, ceramide synthase 1

growth differentiation factor 1
chr4_-_13155135 0.515 NM_001189
NKX3-2
NK3 homeobox 2
chr17_+_26742903 0.514 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr22_+_16973556 0.514 TUBA8
tubulin, alpha 8
chr10_-_135232865 0.512 NM_130784
SYCE1
synaptonemal complex central element protein 1
chr1_+_43769065 0.508 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr1_-_38285033 0.508 NM_002699
POU3F1
POU class 3 homeobox 1
chr9_-_138772506 0.508 NM_178469
LCN8
lipocalin 8
chr6_+_96570565 0.507 NM_006581
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr20_-_3097070 0.506 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr9_+_102275310 0.506 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr8_+_69027166 0.506 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr2_+_104838177 0.505 NM_006236
POU3F3
POU class 3 homeobox 3
chr10_-_73518315 0.504 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr17_-_4967120 0.504 NM_014519
ZNF232
zinc finger protein 232
chr9_-_16860719 0.504 NM_017637
BNC2
basonuclin 2
chr22_+_36531059 0.501 NM_005318
H1F0
H1 histone family, member 0
chrX_+_23262905 0.496 NM_173495
PTCHD1
patched domain containing 1
chr7_+_44110527 0.494 AEBP1
AE binding protein 1
chr22_+_27609889 0.492 NM_032173
ZNRF3
zinc and ring finger 3
chr14_-_37795290 0.491 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr20_+_44091265 0.490 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chrX_-_47394808 0.490 ELK1
ELK1, member of ETS oncogene family
chr4_-_41848874 0.489 BEND4
BEN domain containing 4
chr19_-_646460 0.488 NM_214710
PRSS57
protease, serine, 57
chr8_+_22479115 0.486 NM_001018003
SORBS3
sorbin and SH3 domain containing 3
chr18_+_75261231 0.484 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr15_+_30797466 0.482 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr4_+_996251 0.482 NM_021923
FGFRL1
fibroblast growth factor receptor-like 1
chr17_-_45562112 0.482 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr7_+_44110470 0.481 NM_001129
AEBP1
AE binding protein 1
chr3_-_22389126 0.477 ZNF385D
zinc finger protein 385D
chr12_+_56290229 0.476 NM_001111270
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr7_-_94123308 0.474 SGCE
sarcoglycan, epsilon
chr17_+_37222731 0.474 FKBP10
FK506 binding protein 10, 65 kDa
chr10_+_26545241 0.474 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr17_+_37222726 0.471 FKBP10
FK506 binding protein 10, 65 kDa
chr9_-_103540038 0.470 GRIN3A
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
327.44 2.56e-03 GO:0072177 mesonephric duct development
261.96 4.27e-03 GO:0072163 mesonephric epithelium development
261.96 4.27e-03 GO:0072164 mesonephric tubule development
261.96 4.27e-03 GO:0072176 nephric duct development

Nothing significant found in compartment category.

Nothing significant found in function category.